Structured exercise can improve strength and quality of life in people with transthyretin amyloid cardiomyopathy (ATTR-CM), according to a recent review published in the Journal of Clinical Medicine.
People with ATTR-CM often experience fatigue and have a limited ability to do physical activities. Recent studies show that simple measures of physical ability, such as how far a patient can walk in six minutes or how much oxygen their body uses during exercise testing, are strong predictors of survival.
The review’s authors said this means that treatment for ATTR-CM should go beyond controlling the disease itself: It should also focus on rehabilitation, which can help patients regain stamina, improve quality of life, and possibly even enhance long-term health outcomes.
Read more about treatment and care for ATTR-CM
The review’s authors recommend a structured rehabilitation program that combines aerobic exercise (such as walking, running, swimming and cycling) and strength training (like lifting light weights or using resistance bands).
Although research on ATTR-CM and exercise is still limited, studies in other heart conditions — such as hypertrophic cardiomyopathy and heart failure — have shown that structured exercise programs can safely improve fitness and overall well-being. “These results indicate that appropriately selected CA patients might also gain from customized exercise programs,” the review’s authors said.
Early studies in ATTR-CM patients show that aerobic training is both safe and practical. The best results so far have been seen in patients who start with lower levels of heart stress and better physical fitness.
An ongoing study called the ERICA trial is testing the benefits of a holistic rehabilitation program for people with ATTR-CM. The program combines aerobic exercise, nutrition counseling, psychological support and smoking cessation guidance. Researchers hope that the results will help guide doctors in developing safe, effective rehabilitation plans for the future.
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